Downregulation of NudCD1 in tumor cells that showed a high expression of the protein resulted in a down-regulation of some oncogenic genes such as CTSL, MMP15, uPAR, VEGF, COX-2, S100A4, MUC1, MDM2 and RAC110 and an increase of the resistance to 5-fluorouracil-induced apoptosis11. This evidence concerns the gene MMP15 and neoplasm.