BRCA1 and Familial prostate cancer: Across all cancer types, only 45% of bi-allelic alterations in HR-related genes occurred in traditional BRCA1/2-associated hereditary cancers (hereditary breast and ovarian cancer (HBOC), namely breast, ovarian, and prostate cancer), suggesting that this pathway is altered in other malignancies (Fig. 1b, Supplementary Fig. 1d, Supplementary Data 3).