CDK13 and congenital heart disease: Mutations in CDK13 had not previously been linked to human disease, until recent analysis of exome sequencing data arising from the Deciphering Developmental Disorders (DDD) study.2 In subanalysis of 398 trios affected by syndromic congenital heart disease (S-CHD), in which the proband did not have a plausible de novo mutation in a known developmental disorder-associated or CHD-associated gene, a significant clustering of de novo mutations in CDK13 was observed.