KDR and cancer: Apart from choice due to gene function, IL-1β RNA was chosen for analysis because it encoded a hub in the interactome (Fig. 5), VTCN1 and DSG1 were chosen as representatives of very highly significantly altered RNAs, KRT10 was chosen as a differentiation marker, KDR was chosen as an RNA potentially involved in cancer formation, and SERPINB3 was chosen because it was an early identified cervical cancer marker (39).