APP and acute myocardial infarction: Although not significant after multiple testing correction, artery–coronary showed nominal enrichment in four tissue-relevant pathways (uncorrected P ≤ 0.016 for all): the ACE2 pathway, which regulates heart function; the acute myocardial infarction (AMI) pathway; the intrinsic prothrombin activation pathway, which is involved in one phase of blood coagulation; and the platelet amyloid precursor protein (APP) pathway, which includes genes involved in anti-coagulation functions.