The cross-talk signaling events between ovarian cancer cells and peritoneum include increased expression of integrins, chemokine receptors (CXCRs), CXC chemokine ligands (CXCLs), matrix metalloproteinases (MMPs), urokinase-type plasminogen activator (uPA) and lysophosphatidic acid [9–12]. This evidence concerns the gene PLAU and ovarian cancer.