CTHRC1 and cancer: The univariate analysis showed that CTHRC1 (P = 0.006), tumor grade (P = 0.111), histological subtypes (P = 0.068) and ascites-derived cancer cells (P = 0.018) might have influence on the metastasis, while the multivariate analysis confirmed that the CTHTRC1 expression (odds ratio (OR) = 3.66; P = 0.016) was an independent predictor of ovarian cancer metastasis (Tables 3 and 4).