The occurrence and development of EMT are stimulated by some cytokines and growth factors, such as TGF-β1, hepatocyte growth factor (HGF) and epidermal growth factor (EGF) etc. TGF-β1 is the strongest inducer among them and is overexpressed in many types of human cancers, including SS [10]. The gene discussed is TGFB1; the disease is cancer.