Using a broad antibody panel to 16 different chemokine receptors, our study showed that T lymphocytes which had infiltrated into colorectal carcinoma tissue differed significantly in their expression of CCR2, CCR9, and CXCR5, thus displaying a distinct chemokine receptor profile as compared with T lymphocytes in unaffected colonic mucosa. Here, CXCR5 is linked to colorectal carcinoma.