IHC analysis of MPNST samples revealed that CXCR4 was mainly expressed in the cytoplasm and membrane (Fig. 1a), CXCL12 was present in the cytoplasm and plasma membrane (Fig. 1b), and Cyclin D1 was predominantly localized in the nucleus (Fig. 1c). The gene discussed is CXCL12; the disease is malignant peripheral nerve sheath tumor.