In order to strengthen the role of PPARγ in mediating the reduction in the number of cells induced by the stimulation of “PI(4,5)P2/PLC pathway”, both B16-F10 cells and Mel 13 human melanoma cells were stimulated with 3 M3, for 24 and 48 h, in the presence or absence of GW9662, as an inhibitor of PPARγ [29]. The gene discussed is HSPG2; the disease is melanoma.