On the contrary, ectopic re-expression of KHSRP-WT or KHSRP-K87R in DU145-shKHSRP cells decreased cell penetrating into the matrix; in particular, cells re-expressing KHSRP-K87R grew into tighter and round colonies (Fig. 3c), which suggested the disruption of KHSRP SUMOylation potentially decreased the invasive ability of tumor cells. The gene discussed is KHSRP; the disease is neoplasm.