Compared with KHSRP-WT, re-expression of KHSRP-K87R into stable cell line DU145-shKHSRP, a subset of miRNAs such as let-7 family were upregulated (Fig. 4d-e; Additional file 10: Table S4) and consequently the tumor-suppressive capabilities were enhanced (Fig. 3a-e). The gene discussed is KHSRP; the disease is neoplasm.