AGO2 and neoplasm: TARBP2 recruiting Dicer to Ago2 constitutes an RNA-induced silencing complex (RISC)-loading complex (RLC) for miRNA processing and gene silencing [26, 49], and recently we discovered SUMOylation of TARBP2 plays roles in suppression of tumor growth and tumor cell migration by regulating miRNA efficiency rather than influencing the mature miRNA production [26].