INS and Hypoglycemia: The mean number of severe hypoglycaemic episodes as well as the number of nocturnal severe hypoglycaemic events was significantly reduced in participants in the Insulin degludec group compared to the Insulin glargine group (4.9% vs. 6.6% of patients with severe hypoglycaemia; rate ratio 0.73; 95% CI 0.60–0.89; p < 0.001 for superiority; 1.0% vs. 1.9% of patients with nocturnal severe hypoglycaemia; rate ration 0.47; 95% CI 0.31–0.73; p < 0.001 [10]).