More specifically, 17 out of 70 genes (HIST1H4K, HIST1H4L, MAOA, GNG12, HIST1H4A, NRAS, HIST1H4B, HIST1H4H, CALM3, HIST1H4J, HIST1H4C, CALM1, CALM2, HIST1H4D, HRAS, HIST1H4E and HIST1H4F) are involved in alcoholism pathway. This evidence concerns the gene CALM3 and alcohol dependence.