FOXO1 and frontotemporal dementia: Other important targets include: the Ser/Thr kinase MAPK11, the transcription factor FOXO1, the adapter protein CRK, the interleukin IL12B, the Ca2+-dependent phospholipase PLA2G4B, and the cytidylyltransferase PCYT1A. Conversely, MAPK8 is influenced by few perturbed interactions, among which the most important is PRKACG. The latter is the most degree-central Ser/Thr kinase in the FTD-model after MAPK8, and part of the perturbed route MAPK8-PRKACG-GRIN2B-PRKACB (Fig 5).