Remarkably, PLCB3-specific LVs (LV6-9) connect this gene to four FTD-relevant targets: (i) GABRG3, a perturbed/seed GABA receptor, the major inhibitory neurotransmitter in mammalian brain; (ii) IL12B, an osmotic stress-induced cytokine, targeted by MAPK8; (iii) DGKI, a DAG-kinase interacting with the phospholipase PLCB2; and (iv) ARHGAP10, a GTPase activator involved in apoptosis. Here, GABRG3 is linked to frontotemporal dementia.