The core structure of the essential FTD-network (Fig 3) highlights the central role of four biological processes in FTD: (i) WNT/Ca2+ signaling, (ii) response to oxygen-containing compounds (ROCC), (iii) postsynaptic plasticity and Long Term Potentiation (LTP), and (iv) MAPK-JNK signaling. Here, MAPK8 is linked to frontotemporal dementia.