Particularly, in the FTD-network (Fig 2 and S1 Fig) oxidative stress was impacted due to impaired energetic metabolism [52,53] eliciting the activation of stress-responsive receptors, including Frizzled-4 (FDZ4) and EGFR [54–64], and oxidative stress-inducible Serine/Threonine kinases CAMK2A, PRKACG, PRKACB, and PRKG1 [54–83]. The gene discussed is FZD4; the disease is frontotemporal dementia.