GJD2 and Cognitive impairment: The interaction PRKCG-GJD2-TJP1 is one of the perturbation sources acting on CTNNB1. PRKCG is a Ca2+-activated Ser/Thr protein-kinase C (PKC), which mutations are known to be associated with spinocerebellar ataxia, characterized by cognitive impairment, tremor, and sensory loss [109].