A large portion of our model involves the ncWNT pathway, converging to the sink CTNNB1-CREBBP, and targeted by a series of perturbed receptors: ITPR1-CAMK2A, WNT3-FZD4, FGF11-EGFR, and THRB. In the landscape of WNT signalling, the WNT3-FZD4 interaction might be a novel susceptible functional element in FTD. Here, CREBBP is linked to frontotemporal dementia.