At 4 years (48 months) post-infection, Pol-KY9 and Vpr-VL9 depletion made little difference to viral replication, while Gag-KK10 depletion significantly attenuated the ability of CD8+ T-cells to suppress viral replication, suggesting that the majority of bulk CD8+ T-cell-mediated inhibition was Gag-KK10-specific (Fig 4E–4G). The gene discussed is CD8A; the disease is infection.