To initiate infection, DENV has been shown to interact with C-type lectin receptors such as the mannose receptor (MR), Dendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Non-integrin (DC-SIGN) and C-type lectin domain family 5 member A (CLEC5A) [15–18]. Here, CLEC5A is linked to infection.