The meta-analysis suggested that PCNA overexpression in osteosarcoma patients is associated with low OS, but not significantly with DFS (RR = 1.82, 95% CI 1.53–2.18, P = .000; RR = 1.15, 95% CI 0.91–1.44, P = 0.234). Here, PCNA is linked to osteosarcoma.