Pursuing the vascular hypothesis, several pharmacological triggers (such as glyceryl trinitrate (GTN), calcitonin gene-related peptide (CGRP) and pituitary adenylate cyclase-activating peptide (PACAP-38) were found to induce attacks phenotypically indistinguishable from spontaneous migraine in migraine patients [9–11]. Here, ADCYAP1 is linked to migraine disorder.