Grb7 is a signaling adaptor protein that has been specifically targeted through the development of cyclic peptide inhibitors that are able to inhibit proliferation and migration in breast cancer cell lines and reduce tumor metastasis in a mouse model of pancreatic cancer (Tanaka et al., 2006; Pradip et al., 2013). The gene discussed is GRB7; the disease is familial pancreatic carcinoma.