TAC1 and Increased total eosinophil count: When examining the distribution of the three TACs according to sputum inflammatory endotype, two TACs were associated with eosinophilic (TAC1 or TAC3) and neutrophilic (TAC2 or TAC3) inflammation, suggesting that two distinct transcriptional signatures are associated with both sputum eosinophilia and neutrophilia (33).