For ≤2008 samples, 12 genes were highlighted as being statistically significant: TOX, EED, and LCP2 were upregulated in late-stage CTCL, while ATXN7, CHD1, HUNK, TP63, KIT, JUNB, LTBP4, HDAC2, and OTUB2 were expressed preferentially in early-stage CTCL samples (Table 3). This evidence concerns the gene HDAC2 and primary cutaneous T-cell non-Hodgkin lymphoma.