Pathways that are believed to be involved in CTCL pathogenesis include T-cell function/signaling/differentiation, JAK/STAT/NF-κB signaling, cytokine production, chromatin remodeling, cell cycle checkpoint regulation, DNA repair, as well as cancer testis and embryonic stem cell signaling and function (24, 25, 28, 46). Here, SOAT1 is linked to primary cutaneous T-cell non-Hodgkin lymphoma.