NFKB1 and cancer: Pathways that are believed to be involved in CTCL pathogenesis include T-cell function/signaling/differentiation, JAK/STAT/NF-κB signaling, cytokine production, chromatin remodeling, cell cycle checkpoint regulation, DNA repair, as well as cancer testis and embryonic stem cell signaling and function (24, 25, 28, 46).