In mammals, two independent endothelin receptors, EDNRA and EDNRB (Thaete et al., 2007), have been linked to high-altitude pulmonary edemas (Sharma, Singh & Sarkar, 2014), as well as hypertension, cardiac hypertrophy, and coronary artery disease (Schneider, Boesen & Pollock, 2007). Here, EDNRA is linked to cardiac hypertrophy.