Multivariate logistic regression analysis to determine whether diabetes, hypertension, or OPG significantly correlated with PAD diagnosis revealed that only diabetes (odds ratio [OR], 7.120; 95% CI [1.080–46.940]; P = 0.041) and serum OPG level (odds ratio [OR], 1.336; 95% CI [1.108–1.611]; P = 0.002) were independent predictors of PAD in KT patients after statistical adjustment of patient’s characteristics as age, hypertension, KT duration and eGFR (Table 3). The gene discussed is TNFRSF11B; the disease is hypertensive disorder.