If the activity of p70S6 protein kinase is reduced, autophagy can be initiated directly.41,42 In this way, although the effects of SAHA and TRAIL DR5 on two cell lines were slightly different, the present study showed that SAHA and TRAIL DR5 may influence the activity of downstream TOR signaling pathway mainly through MAPK pathway, especially AKTs, and so induce autophagy in breast cancer cells. The gene discussed is RORC; the disease is breast cancer.