The results of SAHA treatment in TRAIL DR5-silenced MCF-7 cells, a ER-positive breast cancer cell line, displayed that AKT1 and ATK2 play important regulatory roles in SAHA-TRAIL DR5 induced autophagy, but AKTs had slight effects on monitoring autophagy in ER-negative cells such as MDA-MB-231. Here, AKT1 is linked to breast cancer.