Being verified by growing evidences, circRNA/miRNA/mRNA regulatory system represents a novel, yet important, layer of epigenetic control over gene expression in physiological (cartilage degradation, insulin secretion, etc.)[18, 40] and pathological processes (cancer, sporadic AD, cerebral ischemia-reperfusion injury, heart failure, etc.)[16, 17, 32, 41, 42]. This evidence concerns the gene INS and cancer.