TLR4 and diabetic kidney disease: There are reports that diabetic nephropathy has not occurred in TLR4 KO mice [30–35] but the TLR4 antagonist eritoran administration did not affect survival of diabetic mice administered Pg-LPS which has a poor ability to activate TLR4 signaling for Pg-LPS, suggesting that the Pg-LPS-induced diabetic nephropathy is dependent on both TLR2 and TLR4 signaling.