Moreover, SUV39H1 seems to play an important role in controlling the proliferative status of a cell, through alterations of the chromatin structure at centromere region during the process of cell division (Aagaard et al., 2000), the organization of the nuclear architecture (Uhlirova et al., 2010), the inhibition of cell differentiation in transgenic mice overexpressing SUV39H1 (Czvitkovich et al., 2001), and the reduction of viability along with increased genomic instability and susceptibility to cancer found in SUV39H1/2 knockout mice (Peters et al., 2001). Here, SUV39H1 is linked to cancer.