Heterozygous gain-of-function mutations of IFIH1 cause autosomal dominant autoimmune disorders, namely systemic lupus erythematosus (SLE) in mice (Funabiki et al., 2014), and SLE, Aicardi-Goutieres syndrome (AGS) or Singleton-Merten syndrome (SMS) in humans (Oda et al., 2014; Rice et al., 2014; Rutsch et al., 2015; Van Eyck et al., 2015). Here, IFIH1 is linked to systemic lupus erythematosus.