As shown in Figure 1, 88% of B cells from GPA patients and 74% of B cells from HC within the PBMCs fraction consist of transitional/naïve B cells, which according to the report by Wulff et al., are less prone to be suppressed in proliferation by ShK compared to IgD+ B cells. The gene discussed is SHPK; the disease is granulomatosis with polyangiitis.