Treatment strategies affecting B cell survival, comprised of anti-BAFF with or without simultaneous blockade of a proliferation-inducing ligand (i.e., belimumab, tabalumab, and atacicept), have failed to show sufficient efficacy in clinical trials for treatment of systemic lupus erythematosus, rheumatoid arthritis (RA), and multiple sclerosis (29–34). The gene discussed is TNFSF13B; the disease is rheumatoid arthritis.