TNFSF13B and multiple sclerosis: Treatment strategies affecting B cell survival, comprised of anti-BAFF with or without simultaneous blockade of a proliferation-inducing ligand (i.e., belimumab, tabalumab, and atacicept), have failed to show sufficient efficacy in clinical trials for treatment of systemic lupus erythematosus, rheumatoid arthritis (RA), and multiple sclerosis (29–34).