While type I NKT cells have been shown to assume immune-suppressive role in several tumor settings (158–161), a recent study showed that CpG-activated type II NKT cells secreted IFN-γ rather than IL-13, which in turn enhanced the activation and function of CD8+ T cells and contributed to the antitumor effect of CpG in the B16 melanoma model (162). Here, IFNG is linked to melanoma.