The cGAS-STING pathway is critical for activating the type I IFN pathway upon HCMV infection in primary human umbilical vein endothelial cells (HUVEC) and monocytic leukemia cell line THP-1 (Lio et al., 2016; Paijo et al., 2016). This evidence concerns the gene STING1 and cytomegalovirus infection.