Although IFI16 knockdown (KD) enhances HCMV replication (Gariano et al., 2012), a recent study indicates that cGAS, but not IFI16, is required for the STING signaling pathway in human fibroblast upon HCMV infection (Diner et al., 2016). Here, STING1 is linked to cytomegalovirus infection.