High AGE-containing diets induce insulin resistance; on the other side, AGE restriction in food ameliorates insulin signaling, and increases sirtuin-1 expression and AGER-1 that mitigate deleterious gene expression elicited by the AGE/RAGE axis (Cai et al., 2012; Vlassara et al., 2016). The gene discussed is DDOST; the disease is Insulin resistance.