GHSR and epilepsy: Although we could not establish if this last finding was related to antagonism at the ghrelin receptor, it was certainly worth to further investigate this pharmacological activity of EP-80317 in view of the well-recognized need of antiepileptogenic drugs to prevent the appearance of epilepsy in subjects exposed to this risk, as in the case of patients which develop SE and, for this reason (Santamarina et al., 2015), may become affected by epilepsy.