Rare de novo and inherited deletions (and less frequent duplications) at the CDH13 locus have been linked to autism spectrum disorders (Sanders et al., 2011, 2015), indicating potential clinical relevance for loss-of-function mutations in CDH13. An association of CDH13 SNPs with the personality trait of extraversion (Terracciano et al., 2010) and extremely violent behavior (Tiihonen et al., 2015) was also reported. Here, CDH13 is linked to autism spectrum disorder.