Having knowledge of the versatile behavior of CDDO, we set forth a question “Could CDDO induce differentiation of neuroblastoma as well?” After treating the neuroblastoma cells with CDDO, we expected alterations in the following attributes: morphological changes, up-regulation of markers for differentiation, decrease in MYCN levels and finally activation of essential signaling pathways. The gene discussed is MYCN; the disease is neuroblastoma.