A recent study revealed that IFN-deficient mice are highly susceptible to lethal ZIKV infection.47 Therefore, to evaluate prophylactic efficacy, AG6 mice were inoculated with a cocktail of antibodies (0.25 mg m301 and 0.25 mg m302) and then challenged (i.p.)4 h later with 103 PFU of ZIKV strain SZ01, instead of 105 PFU as used in the therapeutic study. This evidence concerns the gene IFNA1 and Zika virus infectious disease.