We observed, only at adulthood, that livers from the OF group compared with those from the NF group, showed alterations in insulin-signaling pathway with reduced pIRS-1/IRS-1, pIRS-2/IRS-2, pAkt/Akt and PI3K protein expressions which could be associated with the insulin resistance and glucose intolerance observed in this group. Here, IRS2 is linked to Glucose intolerance.