Indeed molecular targets, including RIPK1, RIPK3 and MLKL, have been shown to be involved in multiple disease models where necroptosis is of central pathophysiological relevance, such as: in ischemia-reperfusion injury (including stroke, myocardial infarction, resuscitation, solid organ transplantation or heart surgery) in brain, heart and kidney diseases, and in inflammatory diseases, including moderate to severe Rheumatoid Arthritis (RA), psoriasis, retinal disorders, neurodegenerative diseases and infectious disorders (sepsis, viral infections, parasites, bacterial infections)6,7 (Fig. 1). This evidence concerns the gene RIPK1 and rheumatoid arthritis.