ESRRA and breast cancer: As shown in Fig. 2A (also Supplementary Fig. S1), Eu significantly suppressed the protein expression of c-Myc, which was thought to contribute to breast cancer development and progression28, PGC-1β and ERRα in a dose-dependent manner, resulting in 18-63%, 21-68%, 24-71% reduction at various concentrations of Eu (80-200 μM) in MCF10A-ras cells, respectively.