As shown in Table 1, multiple pathways associated with aggressive biological behaviors in pancreatic cancer were enriched, including FoxO signaling pathway, mTOR signaling pathway, PI3K-Akt signaling pathway, AMPK signaling pathway, MAPK signaling pathway, Ras signaling pathway, HIF-1a signaling pathway and others. This evidence concerns the gene HIF1A and pancreatic neoplasm.