It has been reported that gemcitabine could regulate phosphorylation of multiple proteins and signaling pathways such as HAb18G/CD147-EGFR-pSTAT3 signaling pathways19, Nox/ROS/NF-κB/STAT3 signaling9, EebB220, MRP-221et al., which were involved in regulating cancer stemness and chemoresistance. Here, EGFR is linked to cancer.