As shown in Table 1, multiple pathways associated with aggressive biological behaviors in pancreatic cancer were enriched, including FoxO signaling pathway, mTOR signaling pathway, PI3K-Akt signaling pathway, AMPK signaling pathway, MAPK signaling pathway, Ras signaling pathway, HIF-1a signaling pathway and others. The gene discussed is HIF1A; the disease is familial pancreatic carcinoma.