NRP1 and neoplasm: NRP1 downregulation in the PDAC cell line PANC-1 and NSCLC cell line A549 (KRASmt) resulted in increased tumor growth, whereas NRP1-deficient PDAC BxPC-3 cells and NSCLC H226 cells (KRASwt) exhibited decreased tumor growth as compared to that of parental cells (Fig. 2A–D; Supplemental Fig. 2A).