MAPT and dementia: This assumption is supported by the poorer specificity of Aβ42 compared to t-Tau (0.64 versus 0.86), which reflects a lower ratio of negative cases (i.e., such MCI subjects that will remain stable over a much longer observation period), whereas the sensitivity (a ratio of such MCI cases that characterize with pathological biomarkers and have already progressed to dementia) of Aβ42 is superior to t-Tau (0.74 versus 0.62) and slightly superior to hippocampal volume (0.71).