AKT1 and ischemia: Maruyama and colleagues [22] confirmed that, in a hind limb ischemia mouse model, omentin-1 enhanced blood flow recovery and capillary density in ischemia limbs of wild-type mice, and at the cellular level omentin-1 increased endothelial cell differentiation into vascular-like structures and lowed their apoptotic activity via PI3K/Akt-dependent signaling.