FRMD6 and cancer: Although several proteins such as G protein-coupled receptor (GPCR) [20], Merlin/NF2 [21], or Willin/FRMD6 [22], a homologue of Expanded in Drosophila, can act as either an activator or inhibitor of the Hippo-YAP pathway, whether there are other possible upstream regulators for this pathway in the mammalian cells, especially in human cancer cells are not determined.