Similar expression patterns of LATS1/2, phosphorylated LATS and intranuclear YAP were observed in DU145-shPar3 vs DU145-con cells in vitro (Additional file 2: Figure S5b,c), suggesting again that knockdown of Par3 can inhibit PCa cell migration in vitro and metastasis in vivo, associated with activation of the Hippo pathway. Here, LATS1 is linked to posterior cortical atrophy.