LATS1 and melanoma: Our findings are consistent with a recent report showing that Par3 can promote interaction of PP1A (protein phosphatase 1 catalytic subunit alpha) with LATS1 to dephosphorylate LATS1 and YAP so that the nuclear translocation of YAP is increased to induce cell growth in HEK293T, A375 (a melanotic melanoma cell line) and T-47D (a breast cancer cell line) cells [42].