Given that Par3 promotes PCa metastasis via an inactivation of the Hippo pathway and a consequential enhancement of nuclear translocation of YAP by sequestration of KIBRA from its canonical KIBRA/Merlin/FRMD6 complex, we attempt to investigate potential downstream effectors of YAP, which are associated with metastasis. The gene discussed is NF2; the disease is posterior cortical atrophy.