Interestingly, the olfactory deficit of AD+GG- was rescued in 5xFAD mice with Gad67 haploinsufficiency (AD+GG+) (Fig. 7a and 7b, blue line), consistent with the reduction of Aβ in the olfactory bulb and piriform cortex of AD+GG+ mice. Here, GAD1 is linked to Alzheimer disease.