Loss of imprinting (LOI) of IGF2, aberrant methylation in IGF2/H19-ICR and up- or down-regulation of IGF2 expression, respectively, have been shown to be associated with a number of human tumors including colorectal, breast, liver, bladder, Wilms, ovarian, esophageal, prostate tumors and osteosarcoma [11–21]. Here, IGF2 is linked to osteosarcoma.