DNA methylation analyses in IGF2-DMR0 revealed that RP-BPH and RP-PCa samples are significantly hypomethylated when comparing to TUR-BPH samples (TUR-BPH vs. RP-BPH: p = 0.044; TUR-BPH vs. RP-PCa: p = 0.026, Mann-Whitney U test). This evidence concerns the gene IGF2 and posterior cortical atrophy.