In contrast, the methylation of IGF2/H19-ICR (imprinting control region with a CTCF binding site located between IGF2 and H19 genes, Fig. 1) was not significantly different between the prostate cancer groups TUR-BPH, RP-BPH and RP-PCa (Fig. 2c). Here, IGF2 is linked to benign prostatic hyperplasia.