A separate analyses of datasets from NCBI GEO revealed that TDAG8 gene expression is significantly reduced 4.5-fold in AML (GEO Series ID GSE9476), 2.9-fold in CLL (GEO Series ID GSE22529), 3.6-fold in TCPLL with inv(14)(q11q32) (GEO Series ID GSE5788), 2.7-fold in chronic B-cell lymphocytic leukemia (CBLL) (GSE26725), 3.0-fold in DLBCL (GEO series ID GSE12195), and 2.8-fold in FL (GEO series ID GSE12195) (Fig. 1a–e). Here, GPR65 is linked to B-cell chronic lymphocytic leukemia.