LAMA2 and Duchenne muscular dystrophy: Although LN-111 is not present in the normal adult muscle, it is the most studied LN isoform, also applied as a therapeutic agent in different animal models for muscular dystrophies, such as Duchenne muscular dystrophy (DMD) and merosin-deficient congenital muscular dystrophy type 1A (MDC1A) [22, 67–69].