Within the AGO2 binding sites detected in ERβ + cells (Ct-ERβ only) different binding matrixes were specifically enriched, with several of the corresponding binding factor mRNAs being expressed in the cell, including those for TEAD1-3, known to be involved in tumorigenesis [51], and ARID3A, reported to exert gene regulation activity in BC and other cancers [52]. The gene discussed is ESR2; the disease is cancer.