TIE1 and neoplasm: The C-10, D-12, and E-13 models showed higher protein levels of the ANGPT2, F3, and TIE1 genes than the N-15, R-18, and T-22 models, whereas the NRP2 protein level was higher in the N-15, R-18, and T-22 models than in the C-10, D-12, and E-13 models, as illustrated in Fig. 5 by using a C-10 and a T-22 tumor as representative examples.