High expression of NRP2 has been shown to promote hematogenous metastatic spread in pancreatic adenocarcinoma and clear cell renal cell carcinoma xenografts [65] and the development of lymph node metastases in patients with breast carcinoma [66], papillary thyroid carcinoma [67], and squamous cell carcinoma of the oesophagus [68]. This evidence concerns the gene NRP2 and clear cell renal carcinoma.